4 research outputs found
Technical Diagnostics of Tank Cannon Smooth Barrel Bore and Ramming Device
- Publication venue
- 'Defence Scientific Information and Documentation Centre'
- Publication date
- 11/09/2015
- Field of study
Get PDFThe technical diagnostics of 125 mm tank cannon 2A46 smooth barrel and ramming devices are discussed respectively. Focuses on barrel diagnostics and suggests new procedures based on reconstructed BG20 Gun Barrel Bore Gauge System, measuring internal diameter of the barrel bore. The new system measures throughout the whole barrel bore the inner diameter not only at the beginning of barrel bore as it was usually measured before. Different nature of barrel wear was revealed between barrels firing sub-calibre and high explosive projectiles. A method for ramming device diagnostics is presented. An accurate method was proposed, determining projectile extraction force from barrel, as one of the main ramming device parameters for weapons that are used in all areas of armed forces. Results are based on experimental methods assessing the extraction forces from barrel after projectile loading. These tests were performed as a series of tests with consequent technical diagnostics according to the new Czech Defence Standards (derived from NATO standards). The results are presented as the new methodologies for diagnostics of 125 mm barrel 2A46 and ramming devices of tank T-72 for use by technical logistic units in the Czech Republic Armed Forces
Capability assessment of CNC machining centres as measuring devices
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
- Author
- Abdelhamid N.
- Abdul Rahman D.
- Abdul-Saheb M.
- Abreu P.
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- Publication date
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- Field of study
No full textBackground: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Methods: NAVIGATE ESUS was a double-blinded, randomised, phase 3 trial done at 459 centres in 31 countries that assessed the efficacy and safety of rivaroxaban versus aspirin for secondary stroke prevention in patients with ESUS. For this prespecified subgroup analysis, cohorts with and without PFO were defined on the basis of transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE). The primary efficacy outcome was time to recurrent ischaemic stroke between treatment groups. The primary safety outcome was major bleeding, according to the criteria of the International Society of Thrombosis and Haemostasis. The primary analyses were based on the intention-to-treat population. Additionally, we did a systematic review and random-effects meta-analysis of studies in which patients with cryptogenic stroke and PFO were randomly assigned to receive anticoagulant or antiplatelet therapy. Findings: Between Dec 23, 2014, and Sept 20, 2017, 7213 participants were enrolled and assigned to receive rivaroxaban (n=3609) or aspirin (n=3604). Patients were followed up for a mean of 11 months because of early trial termination. PFO was reported as present in 534 (7·4%) patients on the basis of either TTE or TOE. Patients with PFO assigned to receive aspirin had a recurrent ischaemic stroke rate of 4·8 events per 100 person-years compared with 2·6 events per 100 person-years in those treated with rivaroxaban. Among patients with known PFO, there was insufficient evidence to support a difference in risk of recurrent ischaemic stroke between rivaroxaban and aspirin (hazard ratio [HR] 0·54; 95% CI 0·22–1·36), and the risk was similar for those without known PFO (1·06; 0·84–1·33; pinteraction=0·18). The risks of major bleeding with rivaroxaban versus aspirin were similar in patients with PFO detected (HR 2·05; 95% CI 0·51–8·18) and in those without PFO detected (HR 2·82; 95% CI 1·69–4·70; pinteraction=0·68). The random-effects meta-analysis combined data from NAVIGATE ESUS with data from two previous trials (PICSS and CLOSE) and yielded a summary odds ratio of 0·48 (95% CI 0·24–0·96; p=0·04) for ischaemic stroke in favour of anticoagulation, without evidence of heterogeneity. Interpretation: Among patients with ESUS who have PFO, anticoagulation might reduce the risk of recurrent stroke by about half, although substantial imprecision remains. Dedicated trials of anticoagulation versus antiplatelet therapy or PFO closure, or both, are warranted. Funding: Bayer and Janssen
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
- Author
- A Adami
- A Ali
- A Amelia Pinto
- A Arauz
- A Bacellar
- A Balazs
- A Baranowska
- A Barulin
- A Beinlich
- A Belkin
- A Benjamin
- A Cavallini
- A Chakrabarti
- A Chamorro
- A Corlobe
- A Csanyi
- A Czlonkowska
- A Daineko
- A Danese
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- A De Smedt
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- A Favate
- A Fedin
- A Ferreira
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- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
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